FAP mortality shifts from colorectal to gastroduodenal causes over time
A registry-based analysis of 1917 patients with familial adenomatous polyposis (FAP) compared mortality to the general UK population and examined trends by era and presentation type. The study reported that screen-detected relatives had mortality comparable to the general population, while newly presenting patients had markedly higher mortality; colorectal cancer deaths declined from 64% (pre-2001) to 31% (post-2013), while deaths from duodenal and gastric disease and non-FAP-related causes increased over the same period. The authors state this underscores a need for continued surveillance and broader long-term management strategies.