Tenecteplase Before Thrombectomy Shows No Benefit in Late Basilar Occlusion
A multicenter randomized trial in China (ATTENTION LATE) compared intravenous tenecteplase plus endovascular thrombectomy versus thrombectomy alone in 330 patients with moderate to severe basilar artery occlusion presenting 4.5 to 24 hours after stroke onset. The trial reported that 90-day functional independence rates were nearly identical between groups (30% vs 30%), with similar rates of symptomatic intracranial hemorrhage (5% vs 4%) and 90-day mortality (40% vs 43%). The authors concluded that adding tenecteplase before thrombectomy did not improve functional outcomes compared with thrombectomy alone in this population.