2025 ATA thyroglobulin cutoff may miss recurrences in higher-risk DTC
A retrospective study of 205 patients with differentiated thyroid cancer treated with total thyroidectomy without radioactive iodine evaluated the revised 2025 ATA thyroglobulin cutoff of 2.5 ng/mL. The study reported that this threshold increased the excellent response classification from 76% to 98% and missed no recurrences among ATA low-risk patients, but 3.5% of patients with low-intermediate or higher-risk disease had structural recurrence despite meeting excellent response criteria, with a postoperative Tg cutoff of 0.3 ng/mL showing 100% sensitivity for recurrence in that group.