US Task Force Issues Consensus Update on Serrated Polyposis Syndrome

The US Multi-Society Task Force on Colorectal Cancer reviewed serrated polyposis syndrome (SPS), the most common polyposis syndrome, which it states often goes unrecognized and is diagnosed using WHO clinical criteria based on serrated polyp size, number, and location. The statement reports that individuals with SPS have increased risk of prevalent and incident colorectal cancer, recommends meticulous colonoscopic clearing and frequent surveillance, and notes that no common germline pathogenic variant has been identified for SPS, with genetic testing indicated only when another hereditary syndrome is suspected. It also states that first-degree relatives of SPS patients face heightened colorectal cancer risk.

Most relevant for: Patients diagnosed with or suspected of having serrated polyposis syndrome and their first-degree relatives undergoing colorectal cancer screening.

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