Prospective study reports strong survival after resection for early esophageal cancer

A multicenter prospective cohort study followed 385 patients with esophageal cancer showing muscularis mucosae or shallow submucosal invasion after endoscopic resection (315 squamous cell carcinoma, 70 adenocarcinoma). The study reported 5-year overall survival of 92.3% for SCC and 94.2% for EAC, with similar survival among lymphovascular invasion-negative patients managed without additional treatment. Among LVI-negative SCC patients, lesion size and macroscopic appearance predicted metastatic recurrence, and small type 0-II lesions had a low recurrence rate; the study also reported second primary esophageal cancer rates of 25.8% for SCC and 3.6% for EAC at 5 years.

Most relevant for: Patients with early-stage (pMM/SM1) esophageal squamous cell carcinoma or adenocarcinoma following endoscopic resection, particularly those without lymphovascular invasion.

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