Task Force Issues Consensus Statement on Serrated Polyposis Syndrome

This consensus statement from the US Multi-Society Task Force on Colorectal Cancer reviews serrated polyposis syndrome (SPS), the most common polyposis syndrome, noting it is often unrecognized and diagnosed using WHO clinical criteria based on size, number, and location of serrated polyps. The statement reports that individuals with SPS have increased risk of prevalent and incident colorectal cancer, recommends meticulous colon clearing and frequent surveillance colonoscopy, and states that colorectal surgery is indicated for cancer or polyp burden unmanageable endoscopically. It also notes no common germline pathogenic variant is associated with SPS, germline testing is indicated only when another hereditary syndrome is suspected, and first-degree relatives face heightened CRC risk.

Most relevant for: Patients diagnosed with or suspected of having serrated polyposis syndrome and their first-degree relatives undergoing colorectal cancer screening.

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