5-Year Colonoscopy Surveillance Noninferior to 3-Year After High-Risk Adenoma

An interim analysis of an ongoing 10-year noninferiority trial across eight European countries randomized 10,799 patients with high-risk adenomas to first surveillance colonoscopy at 5 years or 3 years after polyp removal. The trial reported a 5-year cumulative colorectal cancer incidence of 0.77% in the 5-year group versus 0.82% in the 3-year group, meeting the prespecified noninferiority criterion, with no substantial difference in cancer stage distribution or colorectal cancer deaths between groups. The authors note this is an interim analysis, with final results planned at 10 years.

Most relevant for: Patients who have undergone removal of high-risk adenomas (defined as adenomas ≥10 mm, high-grade dysplasia, villous growth, or 3 to 10 adenomas of any kind) and are due for surveillance colonoscopy.

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