ResearchSource: The Journal of Clinical Endocrinology & Metabolism

CAH linked to earlier, more complex hospitalizations across lifespan

A Swiss population-based retrospective cohort study analyzed nationwide hospital data from 2011-2022, comparing 2,020 hospitalizations involving congenital adrenal hyperplasia (CAH) with over 12.5 million hospitalizations without CAH. The study reported that hospitalization incidence in CAH peaked in neonates, infants, and young children, unlike controls where incidence rose with age, and endocrine and metabolic disorders were the leading cause of admission across all age groups, with markedly elevated odds ratios, especially in neonates and infants. The authors also reported a substantially higher comorbidity burden in CAH patients across the lifespan and an increased risk of severe in-hospital outcomes such as ICU admission, with the largest differences seen in neonates and infants, concluding that these findings support the need for heightened awareness and age-specific management strategies.

Most relevant for: Patients with congenital adrenal hyperplasia across all age groups, particularly neonates and infants, who experience earlier and more complex hospitalizations with higher comorbidity burden throughout their lifespan.

Read the original at The Journal of Clinical Endocrinology & Metabolism

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