Declining CGM time in range linked to microvascular complications in type 1 diabetes

A 5-year real-world cohort study of 246 adults with type 1 diabetes at a tertiary referral center examined whether continuous glucose monitoring metrics predict a composite microvascular endpoint of nephropathy, severe retinopathy, and peripheral neuropathy. The study reported that a decrease in time in range of 10% or more was associated with higher complication rates (33.3%) compared with stable (7.9%) or increased (15.0%) time in range, and that this change remained independently associated with outcomes after adjustment for age and baseline time in range. The authors state that change in time in range may add prognostic information beyond HbA1c, but note that further validation is needed before routine clinical implementation.

Most relevant for: Adults with long-standing type 1 diabetes being monitored with continuous glucose monitoring for microvascular complication risk.

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