10-kHz Spinal Cord Stimulation Improves Pain and Sensory Function in PDN Trial

The PDN-Sensory randomized controlled trial compared 10-kHz spinal cord stimulation (SCS) plus conventional medical management (CMM) to CMM alone in 91 participants with painful diabetic neuropathy. The trial reported that significantly more SCS participants achieved pain response and sensory improvement on the modified Toronto Clinical Neuropathy Score, along with a greater increase in intraepidermal nerve fiber density, compared with CMM alone; 8 of 10 hierarchical secondary end points, including sleep and quality of life measures, were also met. The authors state these 6-month findings support clinically meaningful benefit and are consistent with a potential disease-modifying effect that requires longer-term confirmation.

Most relevant for: Patients with painful diabetic neuropathy being considered for spinal cord stimulation as an adjunct to conventional medical management.

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