Trial halted early: intermittent dialysis linked to higher mortality in AKI

A multicenter, open-label noninferiority trial randomized critically ill adults with acute kidney injury to initial intermittent hemodialysis or continuous renal-replacement therapy. The trial reported it was stopped early after interim analyses showed sustained higher mortality with intermittent hemodialysis (63.3% vs 53.6% at day 90, hazard ratio 1.30); the trial concluded that intermittent hemodialysis was not shown to be noninferior to continuous therapy for major adverse kidney events.

Most relevant for: Critically ill patients with acute kidney injury requiring renal-replacement therapy in the ICU setting.

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