Short systemic antibiotics noninferior to long course after orthopedic infection surgery

A multicenter, open-label, noninferiority trial randomized 500 adults who underwent surgery for orthopedic infection with implantation of a local-antibiotic carrier to receive either short (≤7 days) or long (≥4 weeks) postoperative systemic antibiotic therapy. The trial reported definite treatment failure by 12 months in 14.1% of the long-duration group versus 11.1% of the short-duration group, meeting the prespecified noninferiority margin, and reported fewer treatment-related symptoms by week 6 in the short-duration group (17.2% versus 45.2%). Sensitivity analyses in the per-protocol population were consistent with the primary analysis, according to the trial.

Most relevant for: Patients undergoing surgical management of orthopedic infection with implantation of a local-antibiotic carrier.

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