Three distinct phenotypes identified among patients failing to wean from ventilation

A secondary analysis of the WEAN SAFE cohort examined trajectories and outcomes of mechanically ventilated patients who failed to wean by day 90. The study reported that 664 of 4394 patients with at least one separation attempt failed weaning, with ICU mortality of 78% versus 2% in those who weaned successfully, and identified three Failed-Wean phenotypes distinguished by separation attempt count and timing of withdrawal or withholding of life-sustaining therapy (WLST). The authors noted a strong association between a failed first separation attempt, WLST decisions, and higher hazard of ICU mortality, which they state deserves further investigation.

Most relevant for: Critically ill patients undergoing invasive mechanical ventilation who are entering the weaning process in the ICU.

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