This three-paper clinical Series examines peripheral arterial disease (PAD) within the broader atherosclerotic cardiovascular disease spectrum, noting it receives lower research and clinical priority than cardiac and cerebrovascular disease despite similar risk factors. The authors state that PAD is often asymptomatic for years and diagnosed at an advanced stage, at which point 5-year mortality of 30-50% surpasses outcomes reported for severe cancer and acute myocardial infarction; the papers cover disease drivers, combined pharmacological and procedural treatment approaches, and global disparities by region, sex, and socioeconomic group.
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