Meta-analysis links mifepristone induction to fewer cesarean deliveries

A systematic review and meta-analysis of 15 randomized controlled trials (n=1,874) examined mifepristone, a progesterone receptor antagonist, for labor induction in singleton term pregnancies. The pooled analysis found mifepristone was associated with 33% reduced odds of cesarean delivery, higher Bishop scores at 24 hours, shorter induction-to-delivery intervals, and less prostaglandin or oxytocin use compared with control induction methods, with no observed differences in postpartum hemorrhage, NICU admission, or low Apgar scores. The authors note these outcomes were underreported in many studies and that robust safety data remain limited.

Most relevant for: Clinicians managing labor induction in singleton pregnancies at 37 weeks of gestation or beyond.

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