Trial finds IVF outperforms surgery for endometriosis-related infertility

A partially randomized patient preference trial across three Italian centers compared IVF with surgery in infertile women with ultrasound-diagnosed ovarian and deep infiltrating endometriosis who had no prior surgery or IVF. The trial was stopped early after 130 enrollments due to investigators' increasing awareness of markedly higher success with IVF; live birth rates were 57% vs 26% in the randomized cohort and 64% vs 28% in the preference cohort, with a combined relative risk of 2.29 (95% CI 1.41-3.70) favoring IVF. The authors conclude that in this trial, IVF was more effective than surgery for treating infertility in this population.

Most relevant for: Infertile women under 40 with ultrasound-diagnosed ovarian endometriomas or deep infiltrating endometriosis who have not previously undergone endometriosis surgery or IVF.

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