Iodine staining during LEEP linked to more positive margins

A randomized controlled trial comparing loop electrosurgical excision procedure (LEEP) with versus without intraoperative Lugol's iodine staining (IOS) found higher rates of involved resection margins in the IOS group (17.5% vs 7.0%). The trial reported no differences in most procedural outcomes or satisfaction, though the IOS group had less postoperative bleeding intensity and shorter bleeding duration at 14-day follow-up. The authors concluded that LEEP with IOS should not be used routinely in clinical practice based on these findings.

Most relevant for: Patients undergoing colposcopy-directed excisional treatment for cervical dysplasia.

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