Trial finds dobutamine plus norepinephrine lowers postoperative AKI in septic shock

A randomized open-label trial across 39 Chinese hospitals compared intraoperative dobutamine plus norepinephrine to norepinephrine alone in 584 adults with septic shock undergoing surgical source control. The trial reported new-onset or worsening acute kidney injury within 7 postoperative days occurred in 22.8% of the combination group versus 34.7% with norepinephrine alone, with lower SOFA scores and higher urine output also observed, though tachycardia was more frequent in the combination group.

Most relevant for: Adults with septic shock undergoing surgical source control, particularly those at risk for postoperative acute kidney injury.

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