Pre-treatment T cell responses linked to longer HIV control off ART

A pooled analysis of 91 participants from six HIV cure trials examined whether HIV-specific T cell responses measured before analytical treatment interruption (ATI) predicted time to viral rebound. The study reported that participants with higher Gag-specific interferon-gamma and CD8+ T cell proliferation responses before stopping ART had longer duration of virologic control after treatment interruption compared to those with lower responses. The authors state these findings support a role for CD8+ T cells in sustaining virologic control after ART cessation.

Most relevant for: People living with HIV participating in analytical treatment interruption or HIV cure trial protocols.

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