Greater Tumor Resection Linked to Better Survival in High-Risk Neuroblastoma

A Children's Oncology Group trial (ANBL0532) analyzed 326 patients with high-risk neuroblastoma who underwent surgical resection of the primary tumor during induction therapy, comparing complete excision (≥90% removed) with incomplete excision. The trial reported that complete excision was associated with significantly higher 5-year event-free survival (50.3% vs 31.0%) and overall survival (61.8% vs 41.1%), lower cumulative incidence of local progression, and no increase in surgical complications compared with incomplete excision.

Most relevant for: Pediatric patients with high-risk neuroblastoma undergoing multimodality treatment including primary tumor resection and stem-cell transplant.

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