Liver Transplant Outcomes for cHCC-CCA Rival Those for HCC

A single-center study compared liver transplantation (LT) with liver resection (LR) in 111 patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA) diagnosed between 2010 and 2024. The study reported that 5-year overall survival and recurrence-free survival were higher after LT than LR, including among tumors within UCSF criteria, and that LT survival for cHCC-CCA was comparable to that reported for hepatocellular carcinoma. The authors identified macrovascular invasion and poor tumor differentiation as independent predictors of recurrence after LT.

Most relevant for: Patients with combined hepatocellular-cholangiocarcinoma being evaluated for liver transplant versus resection.

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