LBBAP outperforms RV pacing in AV block trial

The LEAP-Block randomized trial compared left bundle-branch area pacing (LBBAP) with right ventricular pacing (RVP) in 482 patients with atrioventricular block and preserved left ventricular ejection fraction requiring high-burden ventricular pacing. The trial reported that LBBAP significantly reduced the 24-month composite outcome of all-cause death, heart failure events, or upgrade to biventricular pacing compared with RVP (2.4% vs 12.5%), driven mainly by fewer heart failure events, with no significant differences in death, biventricular pacing upgrade, complications, or pacing-induced cardiomyopathy.

Most relevant for: Patients with atrioventricular block and preserved left ventricular function requiring high-burden ventricular pacing and the clinicians selecting their pacing strategy.

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