International study details duodenal adenoma and cancer rates in MAP

An international study of 679 individuals with genetically confirmed MUTYH-associated polyposis (MAP) assessed incidence and progression of duodenal disease. Duodenal adenomas were found in 13.4% at first endoscopy and developed in 22.7% of those initially adenoma-free during follow-up, with duodenal cancer diagnosed in 0.74% of participants; adenoma incidence varied significantly by genotype, and at least four of five cancers were located in the distal duodenum. The authors state that future MAP guidelines should consider genotype-specific surveillance recommendations, assessment of the distal duodenum, and polypectomy of all detectable adenomas.

Most relevant for: Individuals with genetically confirmed MUTYH-associated polyposis undergoing duodenal surveillance endoscopy.

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