Maternal Tdap Vaccination Linked to Lower Antibody Levels at Ages 3–4

A clinical trial followed children of Tdap-vaccinated (n=47) versus unvaccinated (n=22) mothers to age 4. At 3 and 4 years, children of vaccinated mothers had lower anti-pertussis toxin and anti-diphtheria toxin IgG concentrations, with low pertussis toxin seropositivity and diphtheria seroprotection rates in both groups; after a preschool acellular pertussis booster at age 4, antibody levels became comparable between groups.

Most relevant for: Children who received maternal Tdap vaccination during pregnancy and are undergoing routine childhood immunization schedules including preschool boosters.

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