Low PET Myocardial Flow Reserve Predicts Outcomes in Chronic Coronary Syndrome

A retrospective single-center study of 168 patients with suspected or established chronic coronary syndrome examined whether uncorrected global myocardial flow reserve (MFR) below 2.0 on 13N-ammonia PET predicted a composite of death, non-fatal myocardial infarction, heart-failure hospitalization, or malignant ventricular arrhythmia. The study reported that MFR below 2.0 was independently associated with this endpoint (hazard ratio 4.52), including in patients without baseline heart failure, and that rate-pressure-product correction reclassified 52 patients, mostly downward, altering risk stratification. The authors state these findings support reporting the uncorrected flow reserve value alongside any corrected value.

Most relevant for: Patients with suspected or established chronic coronary syndrome undergoing myocardial perfusion PET imaging.

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