New PET-based method images Ac-225 therapy with higher SNR than SPECT

Researchers developed time-of-flight cascade gamma-ray imaging (TOF-CGI), a technique that uses PET scanners to image the alpha-emitting radionuclide Ac-225 and its daughter Tl-213, addressing limitations of SPECT such as low detection efficiency and poor signal-to-noise ratio. In phantom studies, TOF-CGI showed roughly 10-fold higher detection efficiency and better SNR than SPECT with a 10-fold shorter scan time, and a pilot scan in a prostate cancer patient injected with [Ac-225]Ac-PSMA-617 detected activity within a known prostate bed tumor with higher SNR than SPECT. The authors state this establishes a PET-based imaging paradigm complementary to SPECT and may extend to other targeted radionuclide therapies.

Most relevant for: Patients undergoing Ac-225-based targeted alpha therapy, such as [Ac-225]Ac-PSMA-617 for prostate cancer, where treatment imaging and dosimetry are relevant.

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