Quantitative flow by CZT-SPECT predicts cardiovascular events independently

A retrospective study of 1,007 patients undergoing dynamic Tc-sestamibi myocardial perfusion imaging on a CZT D-SPECT camera assessed whether quantitative myocardial blood flow (MBF) and myocardial flow reserve (MFR) predict major adverse cardiovascular events (MACEs). Over a median follow-up of 49 months, MACEs occurred in 19.0% of patients, and abnormal flow (stress MBF below 1.96 mL/g/min or MFR below 1.98) was associated with worse MACE-free survival. The study reported that MFR and resting MBF remained independent predictors of MACE after adjusting for clinical risk factors, stress ejection fraction, and stress total perfusion deficit, and that quantitative flow assessment added incremental risk stratification in patients with stress total perfusion deficit under 15%.

Most relevant for: Patients with suspected ischemic heart disease undergoing myocardial perfusion imaging, particularly those with mildly abnormal or low-grade perfusion deficits on stress testing.

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