Levodopa not independently linked to freezing-of-gait after adjustment

A study using two prospective Parkinson disease cohorts, NS-Park (25,602 patients) and PPMI (1,441 patients), examined whether levodopa exposure contributes to freezing of gait (FOG). While unadjusted analyses in the NS-Park cohort showed an association between levodopa use and higher FOG severity and incidence, this association was not significant in PPMI and became nonsignificant in both cohorts after adjusting for disease duration, Hoehn and Yahr stage, and MDS-UPDRS Part III motor scores. The study reported that disease duration, Hoehn and Yahr stage, and motor severity, rather than levodopa exposure, were independently associated with FOG severity and incidence.

Most relevant for: Patients with Parkinson disease being evaluated for freezing of gait and levodopa treatment decisions.

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