Iatrogenic cerebral amyloid angiopathy linked to high recurrent hemorrhage risk

A multinational case series of 82 patients with iatrogenic cerebral amyloid angiopathy (iCAA) found a symptomatic intracerebral hemorrhage (ICH) rate of 19.2 per 100 patient-years after first presentation, the study reports. Patients who initially presented with ICH had a higher recurrence rate (24.6 per 100 patient-years) than those with other presentations, and those exposed via spinal surgery had a lower ICH rate than those exposed via brain surgery or embolization, according to the authors. Despite frequent hemorrhage, mortality was low (7.3%), while cognitive impairment was recorded in just over half of patients at last follow-up.

Most relevant for: Patients diagnosed with iatrogenic cerebral amyloid angiopathy following prior neurosurgical or embolization procedures.

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