15-Year MRI Study Links Eye Shape Trajectories to Myopic Complications

A 15-year MRI substudy of the Zhongshan High Myopia Cohort followed 30 participants (60 eyes) with high myopia and classified globe remodeling into five patterns, finding no deformed eye reverted to a normal spheroidal shape. The study reported that pattern distribution varied by age, with younger eyes more likely to show proportional expansion and older eyes more likely to show focal progression or shape transition, and that eyes developing focal deformation had higher rates of myopic macular degeneration progression, posterior staphyloma, and myopic traction maculopathy independent of axial elongation. The authors describe these findings as a candidate framework for individualized surveillance, pending prospective validation.

Most relevant for: Patients with high myopia (spherical equivalent -6.00 D or worse) being monitored for progressive globe remodeling and sight-threatening complications.

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