AAO review finds injection and sponge MMC comparably effective in trabeculectomy

An American Academy of Ophthalmology literature assessment reviewed 11 studies comparing mitomycin C delivered by sub-Tenon's/subconjunctival injection versus sponge during trabeculectomy. The report states that both methods produced similar rates of surgical success, similar reductions in intraocular pressure and medication burden, and a similar safety profile, though several studies noted more favorable bleb morphology with the injection technique. The report concludes that level I and II evidence supports use of either application method.

Most relevant for: Patients undergoing trabeculectomy with mitomycin C for glaucoma, most commonly primary open-angle glaucoma.

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