Seropositive RA linked to greatest long-term bone loss versus PsA, RA-

A longitudinal study using high-resolution peripheral quantitative computed tomography followed 482 patients with seronegative RA, seropositive RA, or psoriatic arthritis for up to 7 years, measuring bone density, microarchitecture, and biomechanical properties at the radius and MCP joint. The study reported that seropositive RA patients had lower trabecular bone density and the most pronounced trabecular and microarchitectural loss compared with PsA and seronegative RA patients, while PsA patients showed relative cortical preservation. The authors state that sustained remission was associated with preserved bone structure and strength, while high disease activity was associated with deterioration.

Most relevant for: Patients with rheumatoid arthritis or psoriatic arthritis being monitored for skeletal effects of disease activity over long-term follow-up.

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