Five-protein plasma panel linked to high structural damage in AS

A two-cohort proteomics study in ankylosing spondylitis identified plasma protein signatures associated with severity of structural damage, assessed by the SPARCC sacroiliac joint structural score. The study prioritized a five-protein panel (ITGA2B, HSPG2, ITGB1, EPHB2, SAA2) that achieved an AUC of 0.917 for distinguishing high versus low structural damage in an independent validation cohort, outperforming individual biomarkers. The authors state the findings support a dual-pathway model involving systemic inflammation and platelet-extracellular matrix remodeling, and suggest the panel could complement imaging-based assessment.

Most relevant for: Patients with ankylosing spondylitis being evaluated for sacroiliac joint structural damage.

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