Review Outlines Rheumatoid Arthritis Diagnosis and Treatment Pathways

This review describes rheumatoid arthritis as a chronic autoimmune disease affecting 0.74% of US adults, more common in women and peaking at ages 55-75. The review reports that diagnosis relies on clinical history, joint swelling patterns, and often autoantibodies, and states that early treatment with methotrexate as first-line therapy, with escalation to biological DMARDs or JAK inhibitors if remission is not achieved, raises remission or low disease activity rates to approximately 80%.

Most relevant for: Adults newly diagnosed with or being managed for rheumatoid arthritis, particularly those not achieving remission on initial methotrexate-based therapy.

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