Severe hypertensive pregnancy disorders recur in about 15% of cases

A retrospective cohort study using the Premier Inpatient database examined recurrence risk of severe hypertensive disorders of pregnancy (HDP), including severe preeclampsia, HELLP syndrome, and eclampsia, among over 560,000 patients with two or more pregnancies. The study reported that patients with severe HDP in an index pregnancy had a 14.9% risk of recurrence in a subsequent pregnancy (RR 16.0), with the highest risk (22.9%, RR 23.1) seen in those with severe HDP before 28 weeks of gestation; history of HELLP syndrome or eclampsia also conferred elevated recurrence risk of these specific phenotypes, though such recurrences were infrequent. The authors state these findings can inform counseling about future HDP risk.

Most relevant for: Patients with a history of severe preeclampsia, HELLP syndrome, or eclampsia, particularly early-onset disease, who are considering a subsequent pregnancy.

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