Case report details severe unexplained hypoxia in lung cancer patient

A case report describes a 40-year-old woman with stage IV ROS1-rearranged lung adenocarcinoma, previously stable on sequential ROS1-targeted therapy, who developed progressive exertional dyspnea with resting oxygen saturation of 90% dropping to 70%-80% with exertion. The case report notes the absence of fever, cough, edema, syncope, or weight loss, and states that recent tumor imaging had shown stable disease, framing the hypoxia as clinically unexplained by cancer progression alone.

Most relevant for: Patients with metastatic ROS1-rearranged lung adenocarcinoma on targeted therapy who develop new exertional dyspnea or hypoxia.

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