OCT Angiography May Detect Glaucoma Progression Earlier Than OCT or Visual Field

A retrospective cohort study of 180 eyes from the Diagnostic Innovations in Glaucoma Study compared progression detection among OCT, OCT angiography (OCTA), and visual field testing over a mean follow-up of 5.1 years. The study reported that OCTA vessel density detected progression earliest in 37.4% of progressing eyes, with mean lead times of 2.3 years before visual field progression and 1.5 years for OCT CPRNFL thickness before visual field progression; specificity among stable eyes was 75.6% for OCT and 68.9% for OCTA. The authors state these findings suggest a potential complementary role for OCTA in glaucoma monitoring, though the cost-benefit of additional testing requires further evaluation.

Most relevant for: Clinicians monitoring patients with perimetric or preperimetric glaucoma for disease progression.

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