High-dose flu vaccine linked to fewer cardiorespiratory events in meta-analysis

A systematic review and meta-analysis of six randomized controlled trials (593,048 randomizations) compared high-dose inactivated influenza vaccine (HD-IIV) with standard-dose inactivated influenza vaccine (SD-IIV) in adults aged 65 and older. The analysis found HD-IIV was associated with fewer serious cardiorespiratory events, pneumonia events, and heart failure hospitalizations, but no significant differences in hospitalization for pneumonia/influenza, MACE, stroke, or coronary event hospitalizations.

Most relevant for: Adults aged 65 and older, including those with known cardiovascular disease, considered for seasonal influenza vaccination.

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