Lower oxygen delivery during bypass linked to higher mortality

A retrospective cohort study of 4,358 adult cardiac surgery patients examined time-weighted average indexed oxygen delivery (DO2i) during cardiopulmonary bypass and 30-day mortality. The study reported that each 10 ml/min/m2 decrease in DO2i was associated with increased adjusted odds of 30-day mortality (ORadj 1.16), and lower DO2i was also associated with higher rates of acute kidney injury and longer ICU and hospital stays, though not with stroke. The authors state these findings support the clinical relevance of oxygen delivery during bypass and provide rationale for future mechanistic and interventional studies.

Most relevant for: Adult patients undergoing cardiac surgery requiring cardiopulmonary bypass.

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