Nodal metastasis rates in cT1N0 lobular carcinoma match SOUND trial

A retrospective study of 639 patients with cT1N0, hormone receptor-positive/HER2-negative pure invasive lobular carcinoma and normal axillary ultrasound found axillary nodal metastases on surgical pathology in 17.7% of patients, with only 2.3% having extensive nodal involvement. The authors report these rates are comparable to node-positive rates in the SLNB arms of the SOUND (13.7%) and INSEMA (15.1%) trials, and found that lymphovascular invasion was independently associated with nodal positivity on multivariate analysis.

Most relevant for: Patients with early-stage (cT1N0), hormone receptor-positive/HER2-negative invasive lobular breast cancer and a clinically negative axillary ultrasound being considered for sentinel lymph node biopsy versus omission.

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