Childhood and young adult cancer survivors show doubled cardiovascular risk

A systematic review and meta-analysis of 39 cohort studies, including over 536,000 childhood, adolescent, and young adult (CAYA) cancer survivors and 1.8 million cancer-free peers, found survivors had nearly double the risk of incident cardiovascular disease (RR 1.99), equating to 90 excess CVD events per 1000 survivors. The risk was higher among those diagnosed in childhood (RR 2.48) than young adulthood (RR 1.61), and although the relative effect declined with longer follow-up, elevated risk persisted beyond 20 years after diagnosis. The authors state these findings support age-specific and time-sensitive cardiovascular surveillance for this growing survivor population.

Most relevant for: Long-term survivors of childhood, adolescent, and young adult cancers, particularly those diagnosed in childhood, followed in survivorship care settings.

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