Broad-spectrum antibiotics show no benefit for CAP in complex children

A cohort study using target trial emulation compared broad- versus narrow-spectrum antibiotics in 847 hospitalizations of children with medical complexity and nonsevere community-acquired pneumonia. After adjustment for confounding, the study reported no significant differences between groups in time to discharge, progression to severe CAP, or 30-day CAP-related revisits. The authors stated these findings support the use of aminopenicillins for nonsevere CAP in many children with medical complexity.

Most relevant for: Hospitalized children with medical complexity and complex chronic conditions being treated for nonsevere community-acquired pneumonia.

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