Prophylactic cryotherapy reduces retinal detachment risk in type 2 Stickler syndrome

A retrospective comparative case series of 197 patients with genetically confirmed type 2 Stickler syndrome evaluated the Cambridge prophylactic cryotherapy protocol against untreated controls. The study reported that bilateral prophylaxis was associated with a 5.7-fold reduction in retinal detachment risk (3.3-fold in matched analysis), and unilateral prophylaxis after a first-eye detachment was associated with a 10.1-fold reduction in second-eye detachment risk; no serious long-term adverse effects from prophylaxis were reported.

Most relevant for: Patients with genetically confirmed type 2 Stickler syndrome, particularly those at risk of retinal detachment or with prior detachment in one eye.

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