LDH and lymphocyte phenotypes predict death in non-HIV PJP

A retrospective multicentre cohort study of 78 adults with non-HIV Pneumocystis jirovecii pneumonia examined whether admission lactate dehydrogenase and lymphocyte count could define risk phenotypes for in-hospital mortality, which was 50.0% overall. The study reported that 30-day mortality rose progressively across four phenotypes, from 12.5% in the lowest-risk group to 64.0% in the combined high-LDH, low-lymphocyte group, with this convergent phenotype independently associated with death alongside CURB-65 score and solid-organ malignancy; the prediction model showed an optimism-corrected AUC of 0.88.

Most relevant for: Hospitalized adults without HIV who are diagnosed with Pneumocystis jirovecii pneumonia.

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