Decade of US uterus transplants: 70% of recipients achieved live birth

A prospective cohort study pooled data from all four US uterus transplant centers between 2016 and 2025, covering 60 transplants, mostly from living donors (70%), performed primarily for Mayer-Rokitansky-Küster-Hauser syndrome. The study reported no deaths or life-threatening complications, reoperation rates of 28.3% in recipients and 14.3% in living donors, and that 70% of recipients achieved at least one live birth or ongoing pregnancy; among 48 neonates, 58.3% were born preterm, and at 3-year follow-up two of 29 children had an autism diagnosis with no other developmental or growth disorders noted.

Most relevant for: Women with absolute uterine factor infertility, including those with Mayer-Rokitansky-Küster-Hauser syndrome, considering uterus transplantation as a path to childbearing.

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