Booster and updated COVID-19 vaccines linked to lower hospitalization in rheumatic disease

A retrospective cohort study using National Clinical Cohort Collaborative data examined 60,980 adults with autoimmune rheumatic conditions who developed COVID-19 between December 2020 and August 2024. The study reported that adjusted odds of COVID-19-related hospitalization decreased progressively with vaccination status, with booster (aOR 0.29) and updated 2023-2024 vaccine (aOR 0.31) recipients showing lower odds than unvaccinated patients, and an absolute risk reduction of 5.6% comparing initial series alone versus booster/updated vaccination.

Most relevant for: Adults with autoimmune rheumatic conditions being considered for COVID-19 vaccination, including booster or updated vaccine doses.

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