RFA and myomectomy show similar symptom relief for fibroids at 2 years

The ULTRA study, a multicenter prospective cohort of 401 premenopausal women with symptomatic uterine leiomyomas, compared laparoscopic radiofrequency ablation (RFA) with myomectomy using validated symptom and quality-of-life measures over 24 months. Both treatments produced significant and sustained improvements, and while myomectomy showed statistically greater reductions in symptom severity and greater HRQOL gains, the study reports these differences fell below thresholds considered clinically meaningful. Early functional advantages for myomectomy at 6 months diminished and were not present by 24 months.

Most relevant for: Premenopausal women with symptomatic uterine leiomyomas considering laparoscopic radiofrequency ablation versus myomectomy.

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