Meta-analysis: half of glaucoma-drainage-device eyes lose EK grafts by 3 years

A systematic review and meta-analysis of 22 retrospective studies (943 grafts) pooled outcomes of endothelial keratoplasty in eyes with prior glaucoma surgery, comparing DSAEK and DMEK. The analysis reported 36-month graft survival of 57% overall and 50% in eyes with prior glaucoma drainage device implantation, with higher endothelial cell loss and graft dislocation rates in GDD eyes; head-to-head comparisons found no significant difference between DSAEK and DMEK through 24 months. The authors state prospective registries with standardized endpoints are needed.

Most relevant for: Patients with prior glaucoma surgery, including glaucoma drainage device implantation, being considered for endothelial keratoplasty.

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