Bronchoscopic Cryospray Improves Symptoms in COPD With Chronic Bronchitis

The SPRAY-CB trial randomized 203 patients with COPD and chronic bronchitis 2:1 to bronchoscopic mucus clearance with or without metered liquid nitrogen cryospray (MCS) using the RejuvenAir System. At 12 months, the trial reported significantly greater improvement in SGRQ and CAT scores with MCS versus sham, along with lower severe AECOPD rates (21.3% vs 26.9%), while periprocedural pneumothorax occurred in 3.6% of treatments and eight deaths were reported, none deemed device- or procedure-related.

Most relevant for: Patients with COPD and chronic bronchitis with productive cough being considered for bronchoscopic interventions.

Summary written by an AI model from the source text and dated by the source's publication date. Check the original before acting on it. How MedFollow selects and summarizes updates.

Informational only. Not medical advice. Not a substitute for clinical judgment. Always consult current guidelines and your own clinical judgment.