EEG patterns worsen progressively in infants with CDKL5 deficiency disorder

A multicenter study of 48 infants and young children with CDKL5 deficiency disorder analyzed 152 longitudinal EEGs from 0-24 months. The study reported that EEG background severity, discontinuity, and generalized slowing increased with age, with 9 months identified as the cutoff age with highest discriminatory value for high-severity (epileptic encephalopathy) EEG findings; lower developmental scores correlated with hypsarrhythmia, epileptic encephalopathy, parieto-occipital epileptiform patterns, and paroxysmal fast activity. The authors state that parieto-occipital paroxysmal fast activity and sequential seizures, though not specific to CDD, are highly suggestive of it.

Most relevant for: Infants and young children under 2 years old with CDKL5 deficiency disorder and early-onset epileptic encephalopathy.

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